Pseudosarcomatous Soft Tissue Lesions: A Review

Pseudosarcomatous soft tissue lesions are potential pitfalls to both clinicians and pathologists due to their clinical presentation, resemblances to malignant lesions and their rarity. They also have a wide range of differential diagnosis histologically due to their relatively non-specific morphology and natural history of evolving features. The difficulty can be exacerbated by samples obtained from curettings or small biopsies as the architecture of the lesion is very helpful in pointing to the correct diagnosis. Familiarity with these entities is needed to avoid misdiagnosis and unnecessarily radical surgery. Despite recent advances in immunohistochemistry and genetic studies, their diagnosis still rest primarily on a combination of clinical history, radiological findings and histologic morphology.