Open AccessCytotoxic Effect ofPuya chilensisCollected in Central Chile
Author(s) -
César Echeverria-Echeverria,
Aly Valderrama-Villarroel,
Marcelo F. Ortega,
Rodrigo A. Contreras,
Gustavo E. Zúñiga,
Leonor Alvarado-Soto,
Rodrigo RamírezTagle
Publication year - 2022
Publication title -
natural product communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.221
H-Index - 44
eISSN - 1934-578X
pISSN - 1555-9475
DOI - 10.1177/1934578x221091671
Subject(s) - cytotoxicity , traditional medicine , cancer cell lines , pharmacology , chemistry , hepatocellular carcinoma , cytotoxic t cell , biology , cancer cell , medicine , biochemistry , cancer , in vitro , cancer research
This study sought to evaluate the pharmacological activity of metabolites isolated from the dried and lyophilized ethanol extracts as well as other solvent fractions of the currently endangered Puya chilensis Molina (Chagual) by analyzing their effects on a human hepatocellular carcinoma (HCC) cell line. We identified several active metabolites from Chagual extracts and two, in particular, carnosol, were found in all the prepared fractions. In addition, Chagual exhibited considerable cytotoxicity against the cancer cell line used in this study, with a half-maximal inhibitory concentration (IC 50 ) of 0.44 ± 0.11 and 0.27 ± 0.04 after a 72-hour treatment and, therefore, has the potential for further investigation as a source of candidate therapeutic agents.