Open AccessChemical Constituents of the Folk Medicinal Plant Argyreia acuta Lour. and Their Anti-Inflammatory Activity
Author(s) -
Yunqing Li,
Xiaoli Zhu,
Liuyan Mo,
Cailan Liu,
Jun Li,
Bing Li,
Jianhua Wei,
Guangfeng Liao,
Rumei Lu
Publication year - 2021
Publication title -
natural product communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.221
H-Index - 44
eISSN - 1934-578X
pISSN - 1555-9475
DOI - 10.1177/1934578x211044563
Subject(s) - phytochemical , coumarin , traditional medicine , chemistry , absolute configuration , stereochemistry , organic chemistry , medicine
Phytochemical investigation of the folk medicinal plant Argyreia acuta Lour. has led to the isolation of a pair of new 3-alkylated coumarin enantiomers, (±)-acutamarin [(±)-1] and 3 known structurally related coumarins (2-4), along with 4 known flavonoids (5-8). The structures of these compounds were elucidated on the basis of extensive spectroscopic (including one-dimensional and two-dimensional nuclear magnetic resonance) analyses and by comparison of their spectral data with those reported in the literature. The absolute configurations of ( − )-1 and ( + )-1 were proposed by comparison of experimental and calculated electronic circular dichroism data. Compounds 5 and 7 exhibited in vitro anti-inflammatory activity by inhibiting the production of nitric oxide with IC 50 values of 24.54 ± 0.36 μM and 10.60 ± 0.15 μM, respectively.