2-Methoxyestradiol Mediates Apoptosis Through Caspase-Dependent and Independent Mechanisms in Ovarian Cancer Cells But Not in Normal Counterparts | Zendy

Sumie Kato | Zendy; Anil Sadarangani | Zendy; Soledad Lange | Zendy; Ana María Delpiano | Zendy; Macarena Vargas | Zendy; Jorge Brañes | Zendy; Jorge Carvajal C | Zendy; Stanley Lipkowitz | Zendy; Gareth I. Owen | Zendy; Mauricio Cuello | Zendy

Open Access

2-Methoxyestradiol Mediates Apoptosis Through Caspase-Dependent and Independent Mechanisms in Ovarian Cancer Cells But Not in Normal Counterparts

Author(s) -

Sumie Kato,

Anil Sadarangani,

Soledad Lange,

Ana María Delpiano,

Macarena Vargas,

Jorge Brañes,

Jorge Carvajal C,

Stanley Lipkowitz,

Gareth I. Owen,

Mauricio Cuello

Publication year - 2008

Publication title -

reproductive sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.927

H-Index - 77

eISSN - 1933-7205

pISSN - 1933-7191

DOI - 10.1177/1933719108324171

Subject(s) - 2 methoxyestradiol , apoptosis , cancer research , ovarian cancer , tumor necrosis factor alpha , cancer cell , biology , chemistry , endocrinology , medicine , cancer , biochemistry

The estrogen metabolite 2-methoxyestradiol has shown antitumorigenic action in some epithelial tumors. In the present work we investigate its effects in ovarian cancer used alone or in combination with other apoptotic-inducing reagents such as tumor necrosis factor-related apoptosis-inducing ligand.

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