Open Access2-Methoxyestradiol Mediates Apoptosis Through Caspase-Dependent and Independent Mechanisms in Ovarian Cancer Cells But Not in Normal Counterparts
Author(s) -
Sumie Kato,
Anil Sadarangani,
Soledad Lange,
Ana M. Delpiano,
Manuel Vargas,
Jorge Brañes,
Jorge Carvajal,
Stanley Lipkowitz,
Gareth I. Owen,
Mauricio Cuello
Publication year - 2008
Publication title -
reproductive sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.927
H-Index - 77
eISSN - 1933-7205
pISSN - 1933-7191
DOI - 10.1177/1933719108324171
Subject(s) - 2 methoxyestradiol , apoptosis , cancer research , ovarian cancer , tumor necrosis factor alpha , cancer cell , biology , chemistry , endocrinology , medicine , cancer , biochemistry
The estrogen metabolite 2-methoxyestradiol has shown antitumorigenic action in some epithelial tumors. In the present work we investigate its effects in ovarian cancer used alone or in combination with other apoptotic-inducing reagents such as tumor necrosis factor-related apoptosis-inducing ligand.