Open AccessClinical effectiveness of convalescent plasma in hospitalized patients with COVID-19: a systematic review and meta-analysis
Author(s) -
Roberto Ariel Abeldaño Zúñiga,
Ruth Ana María González-Villoria,
María Vanesa Elizondo,
A Osorio,
David Gómez Martínez,
Silvia Mercedes Coca
Publication year - 2021
Publication title -
therapeutic advances in respiratory disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.022
H-Index - 37
eISSN - 1753-4666
pISSN - 1753-4658
DOI - 10.1177/17534666211028077
Subject(s) - medicine , convalescent plasma , meta analysis , intensive care medicine , clinical trial , mechanical ventilation , placebo , data extraction , medline , randomized controlled trial , covid-19 , emergency medicine , disease , alternative medicine , law , pathology , political science , infectious disease (medical specialty)
Aims: Given the variability of previously reported results, this systematic review aims to determine the clinical effectiveness of convalescent plasma employed in the treatment of hospitalized patients diagnosed with COVID-19.Methods: We conducted a systematic review of controlled clinical trials assessing treatment with convalescent plasma for hospitalized patients diagnosed with SARS-CoV-2 infection. The outcomes were mortality, clinical improvement, and ventilation requirement.Results: A total of 51 studies were retrieved from the databases. Five articles were finally included in the data extraction and qualitative and quantitative synthesis of results. The overall risk of bias in the reviewed articles was established at low-risk only in two trials. The meta-analysis suggests that there is no benefit of convalescent plasma compared with standard care or placebo in reducing the overall mortality and the ventilation requirement. However, there could be a benefit for the clinical improvement in patients treated with plasma.Conclusion: Current results led to assume that the convalescent plasma transfusion cannot reduce the mortality or ventilation requirement in hospitalized patients diagnosed with SARS-CoV-2 infection. More controlled clinical trials conducted with methodologies that ensure a low risk of bias are still needed. The reviews of this paper are available via the supplemental material section.