Comparative Enhancement of Motor Function and BDNF Expression Following Different Brain Stimulation Approaches in an Animal Model of Ischemic Stroke | Zendy

SerenaKaye Sims | Zendy; Aitana Rizzo | Zendy; Kern Howard | Zendy; Ariana Q. Farrand | Zendy; Heather A. Boger | Zendy; DeAnna L. Adkins | Zendy

Open Access

Comparative Enhancement of Motor Function and BDNF Expression Following Different Brain Stimulation Approaches in an Animal Model of Ischemic Stroke

Author(s) -

SerenaKaye Sims,

Aitana Rizzo,

Kern Howard,

Ariana Q. Farrand,

Heather A. Boger,

DeAnna L. Adkins

Publication year - 2020

Publication title -

neurorehabilitation and neural repair

Language(s) - English

Resource type - Journals

eISSN - 1552-6844

pISSN - 1545-9683

DOI - 10.1177/1545968320952798

Subject(s) - tropomyosin receptor kinase b , brain derived neurotrophic factor , forelimb , stimulation , neurotrophic factors , motor cortex , neuroscience , stroke (engine) , medicine , lesion , inhibitory postsynaptic potential , brain stimulation , excitatory postsynaptic potential , hemiparesis , psychology , receptor , pathology , engineering , mechanical engineering

Combinatory intervention such as high-frequency (50-100 Hz) excitatory cortical stimulation (ECS) given concurrently with motor rehabilitative training (RT) improves forelimb function, except in severely impaired animals after stroke. Clinical studies suggest that low-frequency (≤1 Hz) inhibitory cortical stimulation (ICS) may provide an alternative approach to enhance recovery. Currently, the molecular mediators of CS-induced behavioral effects are unknown. Brain-derived neurotrophic factor (BDNF) has been associated with improved recovery and neural remodeling after stroke and thus may be involved in CS-induced behavioral recovery.

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