Open AccessComparative Enhancement of Motor Function and BDNF Expression Following Different Brain Stimulation Approaches in an Animal Model of Ischemic Stroke
Author(s) -
SerenaKaye Sims,
Aitana Rizzo,
Kern Howard,
Ariana Q. Farrand,
Heather A. Boger,
DeAnna L. Adkins
Publication year - 2020
Publication title -
neurorehabilitation and neural repair
Language(s) - English
Resource type - Journals
eISSN - 1552-6844
pISSN - 1545-9683
DOI - 10.1177/1545968320952798
Subject(s) - tropomyosin receptor kinase b , brain derived neurotrophic factor , forelimb , stimulation , neurotrophic factors , motor cortex , neuroscience , stroke (engine) , medicine , lesion , inhibitory postsynaptic potential , brain stimulation , excitatory postsynaptic potential , hemiparesis , psychology , receptor , pathology , engineering , mechanical engineering
Combinatory intervention such as high-frequency (50-100 Hz) excitatory cortical stimulation (ECS) given concurrently with motor rehabilitative training (RT) improves forelimb function, except in severely impaired animals after stroke. Clinical studies suggest that low-frequency (≤1 Hz) inhibitory cortical stimulation (ICS) may provide an alternative approach to enhance recovery. Currently, the molecular mediators of CS-induced behavioral effects are unknown. Brain-derived neurotrophic factor (BDNF) has been associated with improved recovery and neural remodeling after stroke and thus may be involved in CS-induced behavioral recovery.