Open AccessProceedings of the Sleep and Epilepsy Workshop: Section 3 Mortality: Sleep, Night, and SUDEP
Author(s) -
Gordon F. Buchanan,
Bruce J. Gluckman,
Franck Kalume,
Samden D. Lhatoo,
Rama Maganti,
Jeffrey L. Noebels,
Kristina A. Simeone,
Mark Quigg,
Milena Pavlova
Publication year - 2021
Publication title -
epiliepsy currents/epilepsy currents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 22
eISSN - 1535-7597
pISSN - 1535-7511
DOI - 10.1177/15357597211004556
Subject(s) - epilepsy , sleep (system call) , pathophysiology , medicine , neurology , neuroscience , psychiatry , psychology , computer science , operating system
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy. Likely pathophysiological mechanisms include seizure-induced cardiac and respiratory dysregulation. A frequently identified feature in SUDEP cases is that they occur at night. This raises the question of a role for sleep state in regulating of SUDEP. An association with sleep has been identified in a number of studies with patients and in animal models. The focus of this section of the Sleep and Epilepsy Workshop was on identifying and understanding the role for sleep and time of day in the pathophysiology of SUDEP.