Open AccessWhat do over-trained athletes and patients with neurodegenerative diseases have in common? Mitochondrial dysfunction
Author(s) -
Sergej M. Ostojić,
László Rátgéber,
A. Oláh,
József Betlehem,
Pongrác Ács
Publication year - 2021
Publication title -
experimental biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 146
eISSN - 1535-3702
pISSN - 1535-3699
DOI - 10.1177/1535370221990619
Subject(s) - pathological , mitochondrion , athletes , neurology , medicine , neuroscience , function (biology) , bioinformatics , pathology , physical medicine and rehabilitation , physiology , physical therapy , biology , microbiology and biotechnology
Under pathological conditions and excessive stress, mitochondria may experience a severe and irreversible loss of function. Both strenuous exhaustive exercise and neurodegenerative disorders appear to share defects in mitochondrial function that may fiercely disrupt the integrity and homeostasis of the organelle, leading to perennial pathological substrates. Here, we overview similarities of mitochondrial dysfunction in two conditions and discuss possible areas of interdisciplinary collaboration and research translation between sports medicine and neurology.