Open AccessQuantification of biomechanical properties of human corneal scar using acoustic radiation force optical coherence elastography
Author(s) -
Xiao Han,
Yubao Zhang,
Yirui Zhu,
Yanzhi Zhao,
Hongwei Yang,
Lei Guo,
Sizhu Ai,
Yidi Wang,
Chengfeng Xie,
Jiulin Shi,
Zhang TianYu,
Guofu Huang,
Xiaodong He
Publication year - 2021
Publication title -
experimental biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 146
eISSN - 1535-3702
pISSN - 1535-3699
DOI - 10.1177/15353702211061881
Subject(s) - cornea , elastography , ex vivo , acoustic radiation force , optical coherence tomography , elasticity (physics) , elastic modulus , biomedical engineering , young's modulus , biomechanics , keratoconus , in vivo , ophthalmology , materials science , medicine , optics , ultrasound , anatomy , biology , physics , radiology , microbiology and biotechnology , composite material
Biomechanical properties of corneal scar are strongly correlated with many corneal diseases and some types of corneal surgery, however, there is no elasticity information available about corneal scar to date. Here, we proposed an acoustic radiation force optical coherence elastography system to evaluate corneal scar elasticity. Elasticity quantification was first conducted on ex vivo rabbit corneas, and the results validate the efficacy of our system. Then, experiments were performed on an ex vivo human scarred cornea, where the structural features, the elastic wave propagations, and the corresponding Young's modulus of both the scarred region and the normal region were achieved and based on this, 2D spatial distribution of Young's modulus of the scarred cornea was depicted. Up to our knowledge, we realized the first elasticity quantification of corneal scar, which may provide a potent tool to promote clinical research on the disorders and surgery of the cornea.