Open AccessIntegrating photoacoustic microscopy with other imaging technologies for multimodal imaging
Author(s) -
Arash Dadkhah,
Shuliang Jiao
Publication year - 2020
Publication title -
experimental biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 146
eISSN - 1535-3702
pISSN - 1535-3699
DOI - 10.1177/1535370220977176
Subject(s) - microscopy , photoacoustic imaging in biomedicine , imaging technology , optical imaging , biomedical engineering , materials science , modality (human–computer interaction) , biological imaging , medical imaging , computer science , optics , artificial intelligence , medicine , physics , radiology , fluorescence
As a hybrid optical microscopic imaging technology, photoacoustic microscopy images the optical absorption contrasts and takes advantage of low acoustic scattering of biological tissues to achieve high-resolution anatomical and functional imaging. When combined with other imaging modalities, photoacoustic microscopy-based multimodal technologies can provide complementary contrast mechanisms to reveal complementary information of biological tissues. To achieve intrinsically and precisely registered images in a multimodal photoacoustic microscopy imaging system, either the ultrasonic transducer or the light source can be shared among the different imaging modalities. These technologies are the major focus of this minireview. It also covered the progress of the recently developed penta-modal photoacoustic microscopy imaging system featuring a novel dynamic focusing technique enabled by OCT contour scan.