Open AccessAn overview of neuroblastoma cell lineage phenotypes andin vitromodels
Author(s) -
Sheron Campos Cogo,
Thatyanne Gradowski Farias da Costa do Nascimento,
Fernanda de Almeida Brehm Pinhatti,
Nilton de França,
Bruna Santos Rodrigues,
Luciane R. Cavalli,
Selene Elífio-Esposito
Publication year - 2020
Publication title -
experimental biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 146
eISSN - 1535-3702
pISSN - 1535-3699
DOI - 10.1177/1535370220949237
Subject(s) - neuroblastoma , phenotype , biology , lineage (genetic) , cell lineage , cancer research , in vitro , cell , cell culture , cell type , gene , computational biology , bioinformatics , cellular differentiation , genetics
This review was conducted to present the main neuroblastoma (NB) clinical characteristics and the most common genetic alterations present in these pediatric tumors, highlighting their impact in tumor cell aggressiveness behavior, including metastatic development and treatment resistance, and patients' prognosis. The distinct three NB cell lineage phenotypes, S-type, N-type, and I-type, which are characterized by unique cell surface markers and gene expression patterns, are also reviewed. Finally, an overview of the most used NB cell lines currently available for in vitro studies and their unique cellular and molecular characteristics, which should be taken into account for the selection of the most appropriate model for NB pre-clinical studies, is presented. These valuable models can be complemented by the generation of NB reprogrammed tumor cells or organoids, derived directly from patients' tumor specimens, in the direction toward personalized medicine.