Open AccessGene signature and prognostic merit of M6a regulators in colorectal cancer
Author(s) -
Jinfeng Zhang,
Xiangrong Cheng,
Junzheng Wang,
Yongjie Huang,
Junhui Yuan,
Dawen Guo
Publication year - 2020
Publication title -
experimental biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 146
eISSN - 1535-3702
pISSN - 1535-3699
DOI - 10.1177/1535370220936145
Subject(s) - adenocarcinoma , colorectal cancer , gene signature , biology , gene , cancer research , gene expression , gene expression profiling , oncology , medicine , genetics , cancer
Although new diagnostic techniques and treatments are increasingly updated for CRC, the clinical outcomes of CRC patients are still not encouraging with a low survival rate. N6-methyladenosine (m6A) as a popular modification on mRNA is associated with multiple types of cancers. Our purpose is to identify gene signature and prognostic ability of m6A modulators in CRC. For the first time, we identified genetic changes of m6A modulators and built prognostic gene signature in CRC, which may provide effective targets for the diagnosis and management of CRC.