Open AccessFast intrinsic optical signal correlates with activation phase of phototransduction in retinal photoreceptors
Author(s) -
Xincheng Yao,
Tae-Hoon Kim
Publication year - 2020
Publication title -
experimental biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 146
eISSN - 1535-3702
pISSN - 1535-3699
DOI - 10.1177/1535370220935406
Subject(s) - visual phototransduction , retinitis pigmentosa , retinal , retina , electroretinography , retinal degeneration , photoreceptor cell , biology , retinal regeneration , neuroscience , ophthalmology , medicine
As the center of phototransduction, retinal photoreceptors are responsible for capturing and converting photon energy to bioelectric signals for following visual information processing in the retina. This article summarizes experimental observation and discusses biophysical mechanism of fast photoreceptor-intrinsic optical signal (IOS) correlated with early phase of phototransduction. Quantitative imaging of fast photoreceptor-IOS may provide objective optoretinography to advance the study and diagnosis of age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy, and other eye diseases that can cause photoreceptor dysfunctions.