Open AccessExosomes derived from synovial fibroblasts under hypoxia aggravate rheumatoid arthritis by regulating Treg/Th17 balance
Author(s) -
Yanjie Ding,
Laifang Wang,
Huiqiang Wu,
Qing Zhao,
Shufang Wu
Publication year - 2020
Publication title -
experimental biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 146
eISSN - 1535-3702
pISSN - 1535-3699
DOI - 10.1177/1535370220934736
Subject(s) - rheumatoid arthritis , foxp3 , medicine , immunology , hypoxia (environmental) , arthritis , autoimmune disease , exosome , synovial fluid , autoimmunity , microrna , cancer research , microvesicles , osteoarthritis , antibody , immune system , biology , pathology , gene , chemistry , biochemistry , alternative medicine , organic chemistry , oxygen
A comparative study of osteoarthritis (OA) and RA mice was implemented to suggest that miR-424 expression was increased in RA, and exosome-miR-424 derived from synovial fibroblasts (SFs-exo) could significantly induce T cells differentiation in which Th17 cells increased and Treg cells decreased via targeting FOXP3. And thus, miR-424 may be a potential therapeutic target for RA.