Open AccessHypoxic tumor microenvironment: Implications for cancer therapy
Author(s) -
Sukanya Roy,
Subhashree Kumaravel,
Ankith Sharma,
Camille L. Duran,
Kayla J. Bayless,
Sanjukta Chakraborty
Publication year - 2020
Publication title -
experimental biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 146
eISSN - 1535-3702
pISSN - 1535-3699
DOI - 10.1177/1535370220934038
Subject(s) - tumor microenvironment , hypoxia (environmental) , cancer research , angiogenesis , tumor hypoxia , cancer cell , biology , cancer , medicine , chemistry , radiation therapy , tumor cells , organic chemistry , oxygen
Hypoxia contributes to tumor aggressiveness and promotes growth of many solid tumors that are often resistant to conventional therapies. In order to achieve successful therapeutic strategies targeting different cancer types, it is necessary to understand the molecular mechanisms and signaling pathways that are induced by hypoxia. Aberrant tumor vasculature and alterations in cellular metabolism and drug resistance due to hypoxia further confound this problem. This review focuses on the implications of hypoxia in an inflammatory TME and its impact on the signaling and metabolic pathways regulating growth and progression of cancer, along with changes in lymphangiogenic and angiogenic mechanisms. Finally, the overarching role of hypoxia in mediating therapeutic resistance in cancers is discussed.