Open AccessMicroRNA-892a regulates laryngocarcinoma cell proliferation via Dicer
Author(s) -
Jinhui Dong,
Jianxin Wang,
Chunguang Shan,
Haizhong Zhang,
Xiaohong Ou
Publication year - 2020
Publication title -
experimental biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 146
eISSN - 1535-3702
pISSN - 1535-3699
DOI - 10.1177/1535370220934036
Subject(s) - dicer , gene silencing , microrna , cancer research , cell growth , biology , cancer cell , cancer , apoptosis , flow cytometry , small interfering rna , cell culture , microbiology and biotechnology , transfection , genetics , gene
This work expanded the knowledge of the molecular mechanisms underlying LC progression by exploring the role of miR-892a in the viability of TU212 and M4E cells. The results showed that miR-892a, which exhibited elevated expression in LC cells and tissue specimens of patients with LC, exerted an inhibitory effect on Dicer expression, whereas silencing of miR-892a in TU212 and M4E cells hindered cell proliferation and growth and promoted apoptosis. Furthermore, miR-892a was demonstrated to directly target Dicer 3'-UTR and inhibit its expression. These findings demonstrated that miR-892a acted as an LC oncogene via its action on Dicer, which further confirmed that miR-892a can serve as a diagnostic indicator or promising agent for LC treatment.