Open AccessClinical value of IL-13 and ECP in the serum and sputum of eosinophilic AECOPD patients
Author(s) -
Ting Li,
Li Gao,
Hongxia Ma,
YuSheng Wei,
Yuehua Liu,
Keru Qin,
Wentao Wang,
Hailong Wang,
Min Pang
Publication year - 2020
Publication title -
experimental biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 146
eISSN - 1535-3702
pISSN - 1535-3699
DOI - 10.1177/1535370220931765
Subject(s) - eosinophil cationic protein , sputum , copd , exacerbation , medicine , gastroenterology , eosinophilic , eosinophil , immunology , acute exacerbation of chronic obstructive pulmonary disease , pathology , asthma , tuberculosis
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is an inevitable trend in the development of the disease and eosinophils (EOS) participate in inflammation process. It is important to explore some relatively simple biomarkers in AECOPD which are useful to recognize the disease. In the present study, 108 hospitalized patients with AECOPD were collected and the levels of IL-13 and ECP in the serum and sputum were measured. The levels of IL-13 and ECP in sputum in the eosinophilic group were higher than those in the noneosinophilic group. Moreover, the noneosinophilic group had a higher rate of rehospitalization due to acute exacerbation during the one-year follow-up. The results show that eosinophils in peripheral blood are a simple, convenient, and inexpensive index for assessing the condition and prognosis of AECOPD patients. IL-13 and ECP are involved in the pathogenesis of eosinophilic AECOPD and may be the new targeted anti-inflammatory therapies.