Open AccessGJB4andGJC3variants in non-syndromic hearing impairment in Ghana
Author(s) -
Samuel Mawuli Adadey,
Kevin Esoh,
Osbourne Quaye,
Geoffrey K. Amedofu,
Gordon A. Awandare,
Ambroise Wonkam
Publication year - 2020
Publication title -
experimental biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 146
eISSN - 1535-3702
pISSN - 1535-3699
DOI - 10.1177/1535370220931035
Subject(s) - cohort , hearing loss , genetics , gene , population , medicine , genetic variants , biology , audiology , genotype , environmental health
Although connexins are known to be the major genetic factors associated with HI, only a few studies have investigated GJB4 and GJC3 variants among hearing-impaired patients. This study is the first to report GJB4 and GJC3 variants from an African HI cohort. We have demonstrated that GJB4 and GJC3 genes may not contribute significantly to HI in Ghana, hence these genes should not be considered for routine clinical screening in Ghana. However, it is important to study a larger population to determine the association of GJB4 and GJC3 variants with HI.