Open AccessCircFADS2: A potential prognostic biomarker of colorectal cancer
Author(s) -
Yuchen Xiao,
Huazhang Tong,
Xihong Yuan,
Changhui Xiong,
Xiaoyang Xu,
Yuanfeng Zeng
Publication year - 2020
Publication title -
experimental biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 146
eISSN - 1535-3702
pISSN - 1535-3699
DOI - 10.1177/1535370220929965
Subject(s) - circular rna , colorectal cancer , carcinogenesis , downregulation and upregulation , real time polymerase chain reaction , biomarker , microarray analysis techniques , microarray , gene expression , rna , biology , cancer , cancer research , microrna , metastasis , survival analysis , gene , medicine , genetics
Colorectal cancer (CRC) is the third most common malignancy worldwide with the second highest mortality rate. Although multidisciplinary cooperative therapies are helpful for improving the survival of CRC patients, the prognosis remains poor. Therefore, it is imperative to seek new biomarkers for the development of individualized treatment for each CRC patient. Circular RNA, an endogenous transcript with specific covalent closed loop, exhibits higher stability, conservation and expression abundance than the corresponding linear component and thus may be utilized as a promised biomarker. Although the majority of studies have focused on circular RNA expression profiling in various types of cancers, evidence supporting their critical role in the diagnosis and prognosis of CRC is limited. This study aimed to screen and identify novel circular RNA biomarkers of CRC by chip analysis and qPCR verification, and to highlight their potential as targets for CRC prognosis, and therapy.