Open AccessCircular RNA circ-CDYL sponges miR-1180 to elevate yes-associated protein in multiple myeloma
Author(s) -
Fang Chen,
Xiaohui Wang,
Shuang Fu,
Shaokun Wang,
Fu Shun Yu,
Jihong Zhang,
Zhuogang Liu
Publication year - 2020
Publication title -
experimental biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 146
eISSN - 1535-3702
pISSN - 1535-3699
DOI - 10.1177/1535370220918191
Subject(s) - multiple myeloma , circular rna , pathogenesis , downregulation and upregulation , cancer research , carcinogenesis , in vivo , rna , microrna , apoptosis , chemistry , medicine , microbiology and biotechnology , cancer , gene , biology , genetics , biochemistry
Multiple myeloma (MM) is an extremely complex and heterogeneous disease, and its pathogenesis is poorly understood. Here, we described an important MM-related circular RNA (circRNA), circ-CDYL. It was remarkably increased in both MM cells and plasma. Depletion of circ-CDYL evidently stunted MM growth. Circ-CDYL could absorb miR-1180 and alleviated the repression of miR-1180 on YAP, leading to increased YAP expression, ultimately triggering MM uncontrolled growth. Therefore, our findings advance the understanding of MM pathogenesis, and also raise the possibility of considering circ-CDYL as a potential therapeutic intervention for MM.