Open AccessCurcumin Inhibits Invasiveness and Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma Through Reducing Matrix Metalloproteinase 2, 9 and Modulating p53-E-Cadherin Pathway
Author(s) -
Alan YuehLuen Lee,
Chi-Chen Fan,
Yenan Chen,
Ching-Chang Cheng,
Youngjae Sung,
ChihPing Hsu,
Ting-Yu Kao
Publication year - 2015
Publication title -
integrative cancer therapies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 60
eISSN - 1552-695X
pISSN - 1534-7354
DOI - 10.1177/1534735415588930
Subject(s) - epithelial–mesenchymal transition , cancer research , curcumin , metastasis , matrix metalloproteinase , cancer , cadherin , cancer cell , mmp2 , cell migration , matrigel , biology , pathology , cell , medicine , angiogenesis , pharmacology , genetics
Epithelial-mesenchymal transition (EMT) and invasion play a critical role in cancer progression and metastasis. We have shown that low E-cadherin and high Twist expression are significantly correlated with prognostic survival prediction in oral squamous cell carcinoma (OSCC). This study aimed to determine the anti-invasive effect of curcumin on the expression of matrix metalloproteinases (MMPs) and of EMT regulators in OSCC.