Open AccessElimination of Cancer Stem–Like Side Population in Human Glioblastoma Cells Accompanied With Stemness Gene Suppression by Korean Herbal Recipe MSC500
Author(s) -
ChihJung Yao,
Tae-Young Han,
PingHsiao Shih,
Tsu-Yi Yi,
I-Rue Lai,
KenHu Chang,
Tung-Yuan Lai,
ChiaLun Chang,
Gabriel Y. Lai
Publication year - 2014
Publication title -
integrative cancer therapies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 60
eISSN - 1552-695X
pISSN - 1534-7354
DOI - 10.1177/1534735414549623
Subject(s) - temozolomide , cancer stem cell , medicine , homeobox protein nanog , sox2 , glioma , cancer research , cancer , stem cell , population , side population , oncology , biology , gene , induced pluripotent stem cell , embryonic stem cell , biochemistry , genetics , environmental health
High-grade gliomas are the most common and invasive malignant brain tumors in adults, and they are almost universally fatal because of drug resistance and recurrence. In spite of the progress in adjuvant therapy (like temozolomide) and irradiation after surgery, no effective salvage therapy is currently available for relapsed patients. A Korean herbal recipe MSC500 has been reported to have beneficial therapeutic effects in patients with high-grade gliomas who are relapsed or refractory to conventional treatments. But the underlying molecular mechanisms remain unclear.