Relative Biological Effectiveness and Cell-Killing Efficacy of Continuous Low-Dose-Rate 125I Seeds on Prostate Carcinoma Cells In Vitro | Zendy

Anyan Liao | Zendy; Junjie Wang | Zendy; JiDong Wang | Zendy; Hongqing Zhuang | Zendy; Yong Zhao | Zendy

Open Access

Relative Biological Effectiveness and Cell-Killing Efficacy of Continuous Low-Dose-Rate 125I Seeds on Prostate Carcinoma Cells In Vitro

Author(s) -

Anyan Liao,

Junjie Wang,

JiDong Wang,

Hongqing Zhuang,

Yong Zhao

Publication year - 2010

Publication title -

integrative cancer therapies

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.73

H-Index - 60

eISSN - 1552-695X

pISSN - 1534-7354

DOI - 10.1177/1534735409357758

Subject(s) - in vitro , prostate , oncology , carcinoma , prostate carcinoma , medicine , cancer research , biology , cancer , biochemistry

The aim of this study was to determine the effects of 125 I seeds on prostate carcinoma (PC3) cells. The relative biological effectiveness of 125 I seeds on PC3 cells with respect to 60 Co γ rays was 1.4. Both 4 Gy of 60 Co γ ray and 125 I seed irradiation increased the percentage of cells in G 2 phase, but there was no significant difference between these 2 types of radiation. Significantly, 125 I seeds induced higher apoptotic rates of PC3 cells compared with 60 Co γ ray irradiation. Furthermore, Bcl-2 expression, but not caspase-3 activity, in PC3 cells was downregulated after irradiation with 125 I seed or 60 Co γ rays.

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