
Can the Therapeutic Gain of Radiotherapy Be Increased by Concurrent Administration of Asian Botanicals?
Author(s) -
Stephen M. Sagar
Publication year - 2009
Publication title -
integrative cancer therapies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 60
eISSN - 1552-695X
pISSN - 1534-7354
DOI - 10.1177/1534735409356981
Subject(s) - radiation therapy , medicine , therapeutic effect , traditional chinese medicine , pharmacology , therapeutic index , cancer research , tissue repair , pathology , drug , biomedical engineering , alternative medicine
Therapeutic gain by radiotherapy can be achieved through improved targeting, selectively sensitizing malignant cells, or protecting normal tissue. The majority of synthetic chemical radiation sensitizers and normal tissue protectors have proved to be too toxic at effective clinical doses. However, Asian botanicals (from both Chinese and Ayurvedic medicine) are being evaluated for their ability to improve therapeutic gain through the modulation of reactive oxygen species. An increase in the efficacy of radiotherapy on tumor tissue allows a reduction in the dose applied to normal tissues. In addition, some botanicals may selectively protect normal tissue or increase its repair following radiation therapy. The results are promising enough to consider clinical trials.