Open AccessHydronephrosis alters cardiac ACE2 and Mas receptor expression in mice
Author(s) -
Yanling Zhang,
Lulu Ma,
Junyan Wu,
Tingting Chen
Publication year - 2015
Publication title -
jraas. journal of the renin-angiotensin-aldosterone system/journal of the renin-angiotensin-aldosterone system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 46
eISSN - 1752-8976
pISSN - 1470-3203
DOI - 10.1177/1470320314568439
Subject(s) - losartan , enalapril , hydronephrosis , endocrinology , medicine , angiotensin ii receptor type 1 , receptor , renin–angiotensin system , kidney , blockade , angiotensin ii , chemistry , angiotensin converting enzyme , urinary system , blood pressure
Hydronephrosis is characterized by substantial loss of tubules and affects renin secretion in the kidney. However, whether alterations of angiotensin-converting enzyme (ACE), ACE2 and Mas receptor in the heart are observed in hydronephrosis is unknown. Thus, we assessed these components in hydronephrotic mice treated with AT1 receptor blockade and ACE inhibitor.