Open AccessProtective effects of aliskiren and valsartan in mice with diabetic nephropathy
Author(s) -
Weidong Wang,
Liru Qiu,
Allison Howard,
Nathaniel Solis,
Chunling Li,
Xiaoxin Wang,
Jeffrey B. Kopp,
Moshe Levi
Publication year - 2014
Publication title -
jraas. journal of the renin-angiotensin-aldosterone system/journal of the renin-angiotensin-aldosterone system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 46
eISSN - 1752-8976
pISSN - 1470-3203
DOI - 10.1177/1470320313507123
Subject(s) - aliskiren , valsartan , proinflammatory cytokine , endocrinology , diabetic nephropathy , medicine , pharmacology , kidney , renin–angiotensin system , inflammation , blood pressure
We investigated whether aliskiren, a direct renin inhibitor, provided protection in a model of diabetic nephropathy in mice and compared its protective effects to valsartan, an angiotensin II type 1 receptor blocker.