Paradoxical expressions of natriuretic peptide receptor-C and neutral endopeptidase account for C-type natriuretic peptide decline during the progression of experimental obstructive nephropathy | Zendy

Peng Hu | Zendy; Xue Zhao | Zendy; Jing Wang | Zendy; Hai Bo Kong | Zendy; Bo Hu | Zendy; Ling Lü | Zendy; Yuan Qin | Zendy

Open Access

Paradoxical expressions of natriuretic peptide receptor-C and neutral endopeptidase account for C-type natriuretic peptide decline during the progression of experimental obstructive nephropathy

Author(s) -

Peng Hu,

Xue Zhao,

Jing Wang,

Hai Bo Kong,

Bo Hu,

Ling Lü,

Yuan Qin

Publication year - 2013

Publication title -

journal of the renin-angiotensin-aldosterone system

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 46

eISSN - 1752-8976

pISSN - 1470-3203

DOI - 10.1177/1470320313507121

Subject(s) - natriuretic peptide , medicine , neprilysin , endocrinology , messenger rna , receptor , western blot , endopeptidase , npr1 , npr2 , ligation , chemistry , brain natriuretic peptide , blot , enzyme , heart failure , gene , biochemistry

C-type natriuretic peptide (CNP) selectively binds to the guanylyl cyclase coupled natriuretic peptide receptor (NPR)-B and exerts more potent antihypertrophic and antifibrotic properties. Elimination of CNP occurs mainly by neutral endopeptidase (NEP) and NPR-C.

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