The effects of chronic candesartan treatment on cardiac and hepatic adenosine monophosphate-activated protein kinase in rats submitted to surgical stress | Zendy

Antônio RibeiroOliveira | Zendy; Mirna Bastos Marques | Zendy; Walkíria Wingester Vilas-Boas | Zendy; J. Afonso Guimarães | Zendy; Cândido Celso Coimbra | Zendy; Allan P. Anjos | Zendy; Rodrigo Bastos Fóscolo | Zendy; Robson A.S. Santos | Zendy; Julia Thomas | Zendy; Susana Igreja | Zendy; Blerina Kola | Zendy; Ashley Grossman | Zendy; Márta Korbonits | Zendy

Open Access

The effects of chronic candesartan treatment on cardiac and hepatic adenosine monophosphate-activated protein kinase in rats submitted to surgical stress

Author(s) -

Antônio RibeiroOliveira,

Mirna Bastos Marques,

Walkíria Wingester Vilas-Boas,

J. Afonso Guimarães,

Cândido Celso Coimbra,

Allan P. Anjos,

Rodrigo Bastos Fóscolo,

Robson A.S. Santos,

Julia Thomas,

Susana Igreja,

Blerina Kola,

Ashley Grossman,

Márta Korbonits

Publication year - 2013

Publication title -

journal of the renin-angiotensin-aldosterone system

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 46

eISSN - 1752-8976

pISSN - 1470-3203

DOI - 10.1177/1470320313499199

Subject(s) - candesartan , ampk , protein kinase a , medicine , adenosine , endocrinology , adenosine monophosphate , cyclic adenosine monophosphate , amp activated protein kinase , surgical stress , angiotensin ii , kinase , receptor , chemistry , biochemistry

adenosine monophosphate-activated protein kinase (AMPK) plays a prominent role as a metabolic stress sensor, and it has recently been suggested that the renin-angiotensin system, in addition to its role in stress regulation, may play a significant role in regulating the AMPK system. This study aimed to evaluate the effects of candesartan, an angiotensin II receptor blocker, on cardiac and hepatic AMPK activity basally as well as after surgical stress under general anesthesia.

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