The muscular expression of RAS in patients with achalasia | Zendy

Anna Casselbrant | Zendy; S. Kostic | Zendy; Hans Lönroth | Zendy

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The muscular expression of RAS in patients with achalasia

Author(s) -

Anna Casselbrant,

S. Kostic,

Hans Lönroth

Publication year - 2014

Publication title -

journal of the renin-angiotensin-aldosterone system

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 46

eISSN - 1752-8976

pISSN - 1470-3203

DOI - 10.1177/1470320313498294

Subject(s) - achalasia , chymase , endocrinology , medicine , angiotensin ii , myenteric plexus , renin–angiotensin system , receptor , swallowing , angiotensin receptor , immunohistochemistry , gastroenterology , esophagus , mast cell , immunology , surgery , blood pressure

Angiotensin II (AngII) elicits smooth muscle contractions via activation of AngII type 1 receptor (AT1R) in the intestinal wall and in sphincter regions in several species. Achalasia is a rare swallowing disorder and is characterized by a loss of the wave-like contraction that forces food through the oesophagus and a failure of the lower oesophageal sphincter to relax during swallowing.

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