Open AccessVascular angiotensin II type 2 receptor attenuates atherosclerosis via a kinin/NO-dependent mechanism
Author(s) -
Hitoshi Takata,
Hiroyuki Yamada,
Hiroyuki Kawahito,
Sou Kishida,
Daisuke Irie,
Taku Kato,
Noriyuki Wakana,
Sonoko Miyagawa,
Kensuke Fukui,
Hiroaki Matsubara
Publication year - 2013
Publication title -
jraas. journal of the renin-angiotensin-aldosterone system/journal of the renin-angiotensin-aldosterone system
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 46
eISSN - 1752-8976
pISSN - 1470-3203
DOI - 10.1177/1470320313491794
Subject(s) - endocrinology , apolipoprotein e , medicine , angiotensin ii , nadph oxidase , receptor , kinin , chemistry , oxidative stress , genetically modified mouse , bradykinin , nitric oxide , stimulation , monocyte , renin–angiotensin system , transgene , biology , biochemistry , disease , gene , blood pressure
The angiotensin II (Ang II) type 1 receptor exerts pro-atherogenic action by augmenting oxidative stress, whereas the Ang II type 2 receptor (AT2)-mediated effect on atherosclerosis remains controversial.