Angiotensin modulates human mammary epithelial cell motility | Zendy

Agnieszka Wanda PiastowskaCiesielska | Zendy; Kamila Domińska | Zendy; Magdaleowakowska | Zendy; Małgorzata Gajewska | Zendy; Anna Gajos-Michniewicz | Zendy; Tomasz Ochędalski | Zendy

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Angiotensin modulates human mammary epithelial cell motility

Author(s) -

Agnieszka Wanda PiastowskaCiesielska,

Kamila Domińska,

Magdaleowakowska,

Małgorzata Gajewska,

Anna Gajos-Michniewicz,

Tomasz Ochędalski

Publication year - 2013

Publication title -

journal of the renin-angiotensin-aldosterone system

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 46

eISSN - 1752-8976

pISSN - 1470-3203

DOI - 10.1177/1470320313475904

Subject(s) - motility , microbiology and biotechnology , angiotensin ii , renin–angiotensin system , cell , chemistry , biology , medicine , endocrinology , receptor , biochemistry , blood pressure

Angiotensin II is an effector peptide showing multiple physiological effects, such as regulation of vascular tone, tissue growth and remodelling. Postlactational involution of mammary gland involves changes such as high matrix metalloproteinase activity and release of bioactive fragments of fibronectin and laminin, which may be directly regulated by angiotensin II. The aim of the present study was to evaluate the influence of angiotensin II on proliferation, viability and motility of normal human mammary epithelial cells (184A1 cell line) and to determine the role of angiotensin II receptors in these processes.

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