Open AccessIrbesartan-mediated AT1receptor blockade attenuates hyposmotic-induced enhancement ofIKscurrent and prevents shortening of action potential duration in atrial myocytes
Author(s) -
Jie Wu,
WeiGuang Ding,
Jinchuan Zhao,
Wei-Jin Zang,
Hiroshi Matsuura,
Minoru Horie
Publication year - 2013
Publication title -
jraas. journal of the renin-angiotensin-aldosterone system/journal of the renin-angiotensin-aldosterone system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 46
eISSN - 1752-8976
pISSN - 1470-3203
DOI - 10.1177/1470320312474855
Subject(s) - irbesartan , medicine , endocrinology , myocyte , angiotensin ii , blockade , chemistry , receptor , blood pressure
Stretch of the atrial membrane upregulates the slow component of delayed rectifier K(+) current (I(Ks)). Blockade of angiotensin II subtype 1 receptors (AT(1)R) attenuates this increase in I(Ks). The present study aimed to examine the effects of irbesartan, a selective AT(1)R blocker (ABR), on both the enhancement of I(Ks) and the shortening of action potential duration (APD) induced by stretching atrial myocytes for exploring the mechanisms underlying the prevention of atrial fibrillation (AF) by ABR.