Maternal hyperthyroidism alters the pattern of expression of cardiac renin-angiotensin system components in rat offspring | Zendy

Caroline Antunes Lino | Zendy; Caroline ER Shibata | Zendy; Maria Luiza Morais BarretoChaves | Zendy

Open Access

Maternal hyperthyroidism alters the pattern of expression of cardiac renin-angiotensin system components in rat offspring

Author(s) -

Caroline Antunes Lino,

Caroline ER Shibata,

Maria Luiza Morais BarretoChaves

Publication year - 2012

Publication title -

journal of the renin-angiotensin-aldosterone system

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 46

eISSN - 1752-8976

pISSN - 1470-3203

DOI - 10.1177/1470320312470581

Subject(s) - medicine , endocrinology , offspring , cardiac function curve , renin–angiotensin system , hormone , fetus , pregnancy , biology , heart failure , blood pressure , genetics

Changes in perinatal environment can lead to physiological, morphological, or metabolic alterations in adult life. It is well known that thyroid hormones (TH) are critical for the development, growth, and maturation of organs and systems. In addition, TH interact with the renin-angiotensin system (RAS), and both play a critical role in adult cardiovascular function. The objective of this study was to evaluate the effect of maternal hyperthyroidism on cardiac RAS components in pups during development.

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