Open AccessMaternal hyperthyroidism alters the pattern of expression of cardiac renin-angiotensin system components in rat offspring
Author(s) -
Caroline Antunes Lino,
C. Shibata,
Maria Luíza Morais BarretoChaves
Publication year - 2012
Publication title -
jraas. journal of the renin-angiotensin-aldosterone system/journal of the renin-angiotensin-aldosterone system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 46
eISSN - 1752-8976
pISSN - 1470-3203
DOI - 10.1177/1470320312470581
Subject(s) - medicine , endocrinology , offspring , cardiac function curve , renin–angiotensin system , hormone , fetus , pregnancy , biology , heart failure , blood pressure , genetics
Changes in perinatal environment can lead to physiological, morphological, or metabolic alterations in adult life. It is well known that thyroid hormones (TH) are critical for the development, growth, and maturation of organs and systems. In addition, TH interact with the renin-angiotensin system (RAS), and both play a critical role in adult cardiovascular function. The objective of this study was to evaluate the effect of maternal hyperthyroidism on cardiac RAS components in pups during development.