Open AccessSynergistic effects of angiotensinogen −217 G→A and T704C (M235T) variants on the risk of severe preeclampsia
Author(s) -
Farhad Shahvaisizadeh,
Abolfazl Movafagh,
Mir Davood Omrani,
Asad VaisiRaygani,
Ziba Rahimi,
Zohreh Rahimi
Publication year - 2012
Publication title -
jraas. journal of the renin-angiotensin-aldosterone system/journal of the renin-angiotensin-aldosterone system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 46
eISSN - 1752-8976
pISSN - 1470-3203
DOI - 10.1177/1470320312467555
Subject(s) - preeclampsia , odds ratio , genotype , confidence interval , medicine , allele , renin–angiotensin system , polymorphism (computer science) , pregnancy , endocrinology , gastroenterology , biology , genetics , blood pressure , gene
The rate-limiting step of the renin-angiotensin system is the enzymatic cleavage of angiotensinogen (AGT) by renin. The aims of the present study were to investigate the association between AGT T704C (M235T) and -217 G→A polymorphisms with the risk of preeclampsia and synergistic effects of both polymorphisms on the susceptibility to preeclampsia.