Association of all-trans retinoic acid treatment with the renin-angiotensin aldosterone system expression in glomerulosclerosis rats | Zendy

TianBiao Zhou | Zendy; Weifeng Wu | Zendy; YuanHan Qin | Zendy; Sheng-Sheng Yin | Zendy

Open Access

Association of all-trans retinoic acid treatment with the renin-angiotensin aldosterone system expression in glomerulosclerosis rats

Author(s) -

TianBiao Zhou,

Weifeng Wu,

YuanHan Qin,

Sheng-Sheng Yin

Publication year - 2012

Publication title -

journal of the renin-angiotensin-aldosterone system

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 46

eISSN - 1752-8976

pISSN - 1470-3203

DOI - 10.1177/1470320312465220

Subject(s) - renin–angiotensin system , medicine , endocrinology , retinoic acid , aldosterone , glomerulosclerosis , angiotensin ii receptor type 1 , chemistry , biochemistry , kidney , gene , proteinuria , blood pressure

All-trans retinoic acid (ATRA), a promising therapeutic agent, has been confirmed in animal experiments as playing a protective role against renal diseases. The renin-angiotensin aldosterone system (RAAS) plays a key role in the pathogenesis of renal diseases, and RAAS inhibitors can prevent the progression of kidney diseases. In our previous study, we found that ATRA could play a protective role against glomerulosclerosis (GS) lesions in rats, and its effect was similar to RAAS inhibitors. However, whether ATRA treatment was associated with RAAS expression was not clear.

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