Telomere length is associated with ACE I/D polymorphism in hypertensive patients with left ventricular hypertrophy | Zendy

Frej Fyhrquist | Zendy; Anders Eriksson | Zendy; Outi Saijonmaa | Zendy; Børge G. Nordestgaard | Zendy; Kimmo Kontula | Zendy; Ulf dé Fairé | Zendy; Hans Ibsen | Zendy; Sverre E. Kjeldsen | Zendy; Ingrid Os | Zendy; Björn Dahlöf | Zendy

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Telomere length is associated with ACE I/D polymorphism in hypertensive patients with left ventricular hypertrophy

Author(s) -

Frej Fyhrquist,

Anders Eriksson,

Outi Saijonmaa,

Børge G. Nordestgaard,

Kimmo Kontula,

Ulf dé Fairé,

Hans Ibsen,

Sverre E. Kjeldsen,

Ingrid Os,

Björn Dahlöf

Publication year - 2012

Publication title -

journal of the renin-angiotensin-aldosterone system

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 46

eISSN - 1752-8976

pISSN - 1470-3203

DOI - 10.1177/1470320312460292

Subject(s) - telomere , genotype , left ventricular hypertrophy , medicine , framingham heart study , allele , angiotensin converting enzyme , framingham risk score , muscle hypertrophy , endocrinology , cardiology , biology , genetics , blood pressure , gene , disease

Short telomeres are often associated with cardiovascular risk factors and age-related diseases, while the angiotensin converting enzyme (ACE) gene insertion/deletion polymorphism (DD, ID, II) has shown such associations less consistently. We hypothesized that telomere length and association of telomere length with cardiovascular risk is affected by ACE (I/D) genotype.

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