Evaluation of enalapril affecting the renin-angiotensin system in normal and stress-induced rats based on urinary metabolites of amines and cortisol | Zendy

KV Anil Kumar | Zendy; Sreemantula Satyanarayana | Zendy; Eswar Kumar Kilari | Zendy

Open Access

Evaluation of enalapril affecting the renin-angiotensin system in normal and stress-induced rats based on urinary metabolites of amines and cortisol

Author(s) -

KV Anil Kumar,

Sreemantula Satyanarayana,

Eswar Kumar Kilari

Publication year - 2012

Publication title -

journal of the renin-angiotensin-aldosterone system

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 46

eISSN - 1752-8976

pISSN - 1470-3203

DOI - 10.1177/1470320312460069

Subject(s) - vanillylmandelic acid , enalapril , homovanillic acid , endocrinology , medicine , serotonergic , chemistry , renin–angiotensin system , urinary system , urine , excretion , metabolite , corticosterone , angiotensin converting enzyme , hormone , serotonin , blood pressure , receptor

The renin-angiotensin system is distributed centrally as well as peripherally, which works in association with SNS and HPA in stress. Angiotensin is considered one of the principal hormones for bringing out stress-related changes. To find the influence of enalapril on the neuromediator of CNS and periphery, the present work was carried out. The assessment of the transmitter levels was done by estimating major urinary stress metabolites like vanillylmandelic acid, 5-hydroxyindoleacetic acid, 6-β-hydroxycortisol and homovanillic acid in normal and stress-induced conditions and also in the absence and presence of enalapril treatment in rats.

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