Open AccessAngiotensin II receptor blockade reduces salt sensitivity of blood pressure through restoration of renal nitric oxide synthesis in patients with diabetic nephropathy
Author(s) -
Masahito Imanishi,
Noriyuki Okada,
Yoshio Konishi,
Takashi Morikawa,
Isseki Maeda,
Chizuko Kitabayashi,
Masahiro Morimoto,
Nobuo Shirahashi,
Christopher S. Wilcox,
Akira Nishiyama
Publication year - 2012
Publication title -
jraas. journal of the renin-angiotensin-aldosterone system/journal of the renin-angiotensin-aldosterone system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 46
eISSN - 1752-8976
pISSN - 1470-3203
DOI - 10.1177/1470320312454764
Subject(s) - microalbuminuria , medicine , endocrinology , diabetic nephropathy , valsartan , nitric oxide , nephropathy , excretion , oxidative stress , blood pressure , chemistry , diabetes mellitus
We have previously demonstrated the increased salt sensitivity of blood pressure (BP) in diabetic patients with early nephropathy. Here, we examined the effects of an angiotensin II receptor blocker (ARB) on salt sensitivity and renal oxidative stress or nitric oxide (NO) in those patients.