Open AccessIs there a role of the local tissue RAS in the regulation of physiologic and pathophysiologic conditions in the reproductive tract?
Author(s) -
Lukas Schwentner,
Achim Wöckel,
Daniel Herr,
Christine Wulff
Publication year - 2011
Publication title -
jraas. journal of the renin-angiotensin-aldosterone system/journal of the renin-angiotensin-aldosterone system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 46
eISSN - 1752-8976
pISSN - 1470-3203
DOI - 10.1177/1470320311418140
Subject(s) - renin–angiotensin system , angiotensin ii , endocrine system , reproductive tract , hormone , biology , medicine , pathophysiology , endocrinology , blood pressure
The renin–angiotensin system is well known as a systemic endocrine pathway that regulates blood pressure and salt–water metabolism. In addition to the systemic renin–angiotensin system there is evidence in different species for the presence of a local tissue renin–angiotensin system, which allows local production of the bioactive peptides angiotensin II and angiotensin (1-7). The local renin–angiotensin system has been found in a variety of tissues including tissue of the human reproductive tract. Thus, it was suspected that it may have important functions in the local hormonal microenvironment. Here, a systematic literature search was undertaken to review whether there is evidence for regulatory functions of the local tissue renin–angiotensin system in the human reproductive tract under physiological and pathological conditions.