Open AccessAssociation of angiotensin-converting enzyme intron 16 insertion/deletion polymorphism with history of foetal loss
Author(s) -
Larisa Bukreeva,
Alexandre Grigorov,
H. Kiesewetter,
Berthold Hoppe
Publication year - 2009
Publication title -
jraas. journal of the renin-angiotensin-aldosterone system/journal of the renin-angiotensin-aldosterone system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 46
eISSN - 1752-8976
pISSN - 1470-3203
DOI - 10.1177/1470320309343813
Subject(s) - genotype , odds ratio , medicine , angiotensin converting enzyme , case control study , endocrinology , allele , pathogenesis , renin–angiotensin system , angiotensin ii , polymorphism (computer science) , gastroenterology , biology , genetics , gene , receptor , blood pressure
The angiotensin-converting enzyme (ACE) intron 16 insertion/deletion (I/D) polymorphism is associated with ACE activity and has been discussed as a risk factor for pre-eclampsia. Disturbances of uteroplacental circulation are involved in the pathogenesis of pre-eclampsia. In this study, we tested whether the ACE I/D genotype is associated with history of foetal loss (FL) or uteroplacental dysfunction (UPD).