Angiotensin II type 1 receptor gene polymorphism in myocardial infarction patients | Zendy

Bhoomi Reddy Pullareddy | Zendy; B.M.V. Srikanth Babu | Zendy; Kolla Venkata Karunakar | Zendy; Yasovanthi Jeedigunta | Zendy; P. Sampath Kumar | Zendy; Annam Sharath | Zendy; A. Jyothy | Zendy

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Angiotensin II type 1 receptor gene polymorphism in myocardial infarction patients

Author(s) -

Bhoomi Reddy Pullareddy,

B.M.V. Srikanth Babu,

Kolla Venkata Karunakar,

Yasovanthi Jeedigunta,

P. Sampath Kumar,

Annam Sharath,

A. Jyothy

Publication year - 2009

Publication title -

journal of the renin-angiotensin-aldosterone system

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 46

eISSN - 1752-8976

pISSN - 1470-3203

DOI - 10.1177/1470320309342758

Subject(s) - myocardial infarction , genotype , odds ratio , medicine , angiotensin ii , angiotensin converting enzyme , gene polymorphism , confidence interval , cardiology , angiotensin receptor , polymorphism (computer science) , gastroenterology , receptor , endocrinology , biology , gene , genetics , blood pressure

. Acute myocardial infarction is commonly known as heart attack. It is a multifactorial disease influenced by environmental and genetic factors.The objective of the present study was to investigate the association of the angiotensin II type 1 receptor gene A/C polymorphism in South Indian myocardial infarction patients. Subjects and methods. The present study included a total number of 221 subjects (107 myocardial infarction patients and 114 age- and sex-matched controls). Demographic and clinical characteristics were collected. Lipid profiles were estimated. DNA was isolated and the angiotensin II type 1 receptor gene A/C polymorphism was determined by polymerase chain reaction. Results. Comparison of the lipid profiles between patients and controls showed that patients had statistically highly significant values (p=0.0001).The CC genotype of the angiotensin II type 1 receptor was not associated with myocardial infarction patients when compared to controls. CC vs. AA was χ 2 = 2.08, odds ratio 2.30, 95% confidence interval 0.72 — 7.23, and p value was 0.14. Conclusion. The angiotensin II type 1 receptor CC genotype is not a risk factor for myocardial infarction in patients in a South Indian population.

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