Open AccessTenofovir alafenamide fumarate
Author(s) -
William A Lee,
Andrew Cheng
Publication year - 2022
Publication title -
antiviral therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.747
H-Index - 87
eISSN - 2040-2058
pISSN - 1359-6535
DOI - 10.1177/13596535211067600
Subject(s) - tenofovir alafenamide , emtricitabine , prodrug , tenofovir , pharmacology , cobicistat , chemistry , human immunodeficiency virus (hiv) , medicine , virology , viral load , antiretroviral therapy
Tenofovir alafenamide fumarate is a lipophilic prodrug of tenofovir which is preferentially metabolized in lymphatic tissue resulting in high concentrations of tenofovir (TFV) and its active diphosphate metabolite inside the cells that replicate HIV. Due to its selectivity for these tissues, lower total doses of TAF can be administered relative to tenofovir disoproxil fumarate (TDF) which results in improved bone and renal biomarkers. Tenofovir alafenamide fumarate has become the “backbone” of multiple combination products for the treatment of HIV, combined with emtricitabine for PreP and as a monotherapy for the treatment or HBV.