Open AccessSensitivity of T1/T2-weighted ratio in detection of cortical demyelination is similar to magnetization transfer ratio using post-mortem MRI
Author(s) -
Yufan Zheng,
Jessica Dudman,
Jacqueline T. Chen,
Kedar Mahajan,
Danielle Herman,
Robert J. Fox,
Daniel Ontaneda,
Bruce D. Trapp,
Kunio Nakamura
Publication year - 2021
Publication title -
multiple sclerosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.729
H-Index - 131
eISSN - 1477-0970
pISSN - 1352-4585
DOI - 10.1177/13524585211014760
Subject(s) - multiple sclerosis , magnetic resonance imaging , magnetization transfer , medicine , nuclear medicine , white matter , myelin , pathology , radiology , central nervous system , psychiatry
Detecting cortical demyelination using magnetic resonance imaging (MRI) in multiple sclerosis (MS) remains a challenge. Magnetization transfer ratio (MTR), T1-weighted/T2-weighted ratio (T1T2R), and T2-weighted (T2w) signal are sensitive to cortical demyelination, but their accuracy is unknown.