Open AccessDoege–Potter Syndrome and Hypoglycemia associated with Solitary Fibrous Tumor of the Pleura: Two Case Reports
Author(s) -
Liliana FernándezTrujillo,
Jhon Edwar Bolaños,
Carolina Álvarez,
Julián Giraldo,
Mauricio Velásquez,
Valeria Zúñiga-Restrepo,
Bladimir Pérez,
Luz F. Sua
Publication year - 2020
Publication title -
clinical medicine insights. circulatory, respiratory and pulmonary medicine
Language(s) - English
Resource type - Journals
ISSN - 1179-5484
DOI - 10.1177/1179548420964759
Subject(s) - solitary fibrous tumor , hypoglycemia , medicine , mesenchymal stem cell , thorax (insect anatomy) , biopsy , immunohistochemistry , resection , mesenchymal tumor , refractory (planetary science) , pathology , insulin , surgery , anatomy , biology , genetics , stem cell , cd34 , astrobiology
Solitary fibrous tumors of the pleura (SFTP) are rare mesenchymal neoplasms that originate from mesenchymal growth in the pleura, tend to be single tumors, usually have an indolent course and show nonspecific symptoms. SFTP can be often diagnosed from an incidental finding of a single mass in the thorax and should be confirmed by biopsy and immunohistochemistry. A minority of cases may present Doege–Potter syndrome (DPS, episodes of refractory hypoglycemia) associated with production of insulin-like growth factor 2 (IGF-2). Both SFTP and DPS are rare occurrences with less than 2000 cases reported worldwide. The curative treatment is tumor resection. Two cases of patients with DPS caused by SFTP are presented below.