The Rv3799-Rv3807 Gene Cluster in Mycobacterium Tuberculosis Genome Corresponds to the ‘Ancient Conserved Region’ in CMN Mycolyltransferases | Zendy

Hemalatha Golaconda Ramulu | Zendy; Swathi Adindla | Zendy; Lalitha Guruprasad | Zendy

Open Access

The Rv3799-Rv3807 Gene Cluster in Mycobacterium Tuberculosis Genome Corresponds to the ‘Ancient Conserved Region’ in CMN Mycolyltransferases

Author(s) -

Hemalatha Golaconda Ramulu,

Swathi Adindla,

Lalitha Guruprasad

Publication year - 2006

Publication title -

evolutionary bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.502

H-Index - 32

ISSN - 1176-9343

DOI - 10.1177/117693430600200015

Subject(s) - gene , genome , mycobacterium tuberculosis , gene cluster , conserved sequence , genetics , cluster (spacecraft) , biology , mycobacterium tuberculosis complex , computational biology , tuberculosis , peptide sequence , medicine , computer science , pathology , programming language

We have identified based on gene cluster analysis that the genes between Rv3799–Rv3807 in M. tuberculosis have orthologs in Corynebacteria, Mycobacteria and Nocardia (CMN) genomes. Therefore, this gene cluster possibly corresponds to the ‘Ancient Conserved Region’ of CMN mycolyltransferases. The evolutionary trace analysis suggests that twelve amino acid residues; Leu39, Trp51, Pro71, Trp82, Trp97, Phe100, Gly124, Ser126, Asp192, Glu230, Gly260 and Trp264 are ‘absolutely conserved’. These amino acid residues constitute the active site and conserved hydrophobic tunnel in CMN mycolyltransferases.

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