Open AccessImpact of radioiodine treatment on acute phase proteins in hyperthyroid cats
Author(s) -
Katharina Glück,
Sabrina Mohrs,
Katarina Hazuchova,
Natali Bauer,
Reto Neiger
Publication year - 2021
Publication title -
journal of feline medicine and surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.837
H-Index - 61
eISSN - 1532-2750
pISSN - 1098-612X
DOI - 10.1177/1098612x211024954
Subject(s) - cats , haptoglobin , serum amyloid a , acute phase protein , medicine , orosomucoid , gastroenterology , endocrinology , chemistry , glycoprotein , inflammation , biochemistry
Objectives The aim of this study was to investigate the impact of radioiodine treatment (RIT) on the acute phase proteins (APPs) serum amyloid A (SAA), alpha-1-acid glycoprotein (AGP) and haptoglobin (Hp) in hyperthyroid cats.Methods Between June 2013 and November 2014, 33 hyperthyroid cats without clinical or laboratory signs of inflammatory or neoplastic disease and a body weight >2.5 kg were enrolled. Immediately before, and 12, 36, 72 h and 6 days after RIT, serum samples were obtained for determination of APP concentrations.Results Both SAA and AGP concentrations changed significantly after RIT. The concentration of AGP increased gradually after treatment with a maximum concentration at the end of the study period (median baseline 398 μg/ml; median 6 days post-RIT 562 μg/ml [ P = 0.001]). A relevant >two-fold increase in AGP was seen in 8/33 (24%) cats. SAA concentration increased significantly within 12 h (baseline 9.2 μg/ml; 12 h post-RIT 22.5 μg/ml [ P = 0.012]). In 7/33 (21%) cats, a clinically relevant >10-fold increase in SAA was observed. Hp concentration showed no significant change ( P = 0.12).Conclusions and relevance RIT induced a mild, mainly not clinically relevant acute phase reaction (APR). AGP and SAA were useful APPs to determine RIT-induced APR.