Open AccessACE2 Protein Expression During Childhood, Adolescence, and Early Adulthood
Author(s) -
Bernadette Schurink,
Eva Roos,
Wim Vos,
Marjolein Breur,
Paul van der Valk,
Marianna Bugiani
Publication year - 2022
Publication title -
pediatric and developmental pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.477
H-Index - 60
eISSN - 1615-5742
pISSN - 1093-5266
DOI - 10.1177/10935266221075312
Subject(s) - lung , kidney , context (archaeology) , autopsy , angiotensin converting enzyme 2 , pancreas , pathology , medicine , biology , physiology , endocrinology , receptor , covid-19 , disease , paleontology , infectious disease (medical specialty)
Purpose and context. Angiotensin-converting enzyme 2 is the entry receptor for SARS-CoV and SARS-CoV-2. Variations in ACE2 expression might explain age-related symptomatology of COVID-19, that is, more gastro-intestinal symptoms and less pulmonary complaints. This study qualitatively investigated ACE2 protein expression in various organs from the fetal to the young adolescent stage. Method. Autopsy samples from lung, heart, liver, stomach, small intestine, pancreas, kidney, adrenals, and brain (when available) were obtained from twenty subjects aged 24 weeks gestational age through 28 years. Formalin-fixed paraffin-embedded 4-um-thick tissue sections were stained against ACE2. Key results. We showed that the extent of ACE2 expression is age-related. With age, expression increases in lungs and decreases in intestines. In the other examined organs, ACE2 protein expression did not change with age. In brain tissue, ACE2 was expressed in astrocytes and endothelial cells. Conclusions. Age-related ACE2 expression differences could be one substrate of the selective clinical vulnerability of the respiratory and gastro-intestinal system to SARS-CoV-2 infection during infancy.