Open AccessD-dimer Level and Diabetes in the COVID-19 Infection
Author(s) -
Chaymae Miri,
Hajar Charii,
Mohammed-Amine Bouazzaoui,
Falmata Laouan Brem,
Soumia Boulouiz,
Naïma Abda,
Hatim Kouismi,
Zakaria Bazid,
Mariame Meziane,
Noha El Ouafi
Publication year - 2021
Publication title -
clinical and applied thrombosis/hemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.643
H-Index - 53
eISSN - 1938-2723
pISSN - 1076-0296
DOI - 10.1177/10760296211045902
Subject(s) - medicine , d dimer , diabetes mellitus , gastroenterology , comorbidity , pneumonia , covid-19 , population , receiver operating characteristic , retrospective cohort study , disease , endocrinology , environmental health , infectious disease (medical specialty)
Diabetes is the most common of comorbidity in patients with SARS-COV-2 pneumonia. Coagulation abnormalities with D-dimer levels are increased in this disease.Objectifs We aimed to compare the levels of D-dimer in diabetic and non-diabetic patients with COVID 19. A link between D-dimer and mortality has also been established.Materials A retrospective study was carried out at the University Hospital Center of Oujda (Morocco) from November 01st to December 01st, 2020. Our study population was divided into two groups: a diabetic group and a second group without diabetes to compare clinical and biological characteristics between the two groups. In addition, the receiver operator characteristic curve was used to assess the optimal D-dimer cut-off point for predicting mortality in diabetics.Results 201 confirmed-COVID-19-patients were included in the final analysis. The median age was 64 (IQR 56-73), and 56% were male. Our study found that D-dimer levels were statistically higher in diabetic patients compared to non-diabetic patients. (1745 vs 845 respectively, P = 0001). D-dimer level > 2885 ng/mL was a significant predictor of mortality in diabetic patients with a sensitivity of 71,4% and a specificity of 70,7%.Conclusion Our study found that diabetics with COVID-19 are likely to develop hypercoagulation with a poor prognosis.