D-dimer Level and Diabetes in the COVID-19 Infection | Zendy

Chaymae Miri | Zendy; Hajar Charii | Zendy; Mohammed-Amine Bouazzaoui | Zendy; Falmata Laouan Brem | Zendy; Soumia Boulouiz | Zendy; Naïma Abda | Zendy; Hatim Kouismi | Zendy; Zakaria Bazid | Zendy; Nabila Ismaili | Zendy; Noha El Ouafi | Zendy

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D-dimer Level and Diabetes in the COVID-19 Infection

Author(s) -

Chaymae Miri,

Hajar Charii,

Mohammed-Amine Bouazzaoui,

Falmata Laouan Brem,

Soumia Boulouiz,

Naïma Abda,

Hatim Kouismi,

Zakaria Bazid,

Nabila Ismaili,

Noha El Ouafi

Publication year - 2021

Publication title -

clinical and applied thrombosis/hemostasis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 53

eISSN - 1938-2723

pISSN - 1076-0296

DOI - 10.1177/10760296211045902

Subject(s) - medicine , d dimer , diabetes mellitus , gastroenterology , comorbidity , pneumonia , covid-19 , population , retrospective cohort study , receiver operating characteristic , disease , endocrinology , environmental health , infectious disease (medical specialty)

Diabetes is the most common of comorbidity in patients with SARS-COV-2 pneumonia. Coagulation abnormalities with D-dimer levels are increased in this disease.Objectifs We aimed to compare the levels of D-dimer in diabetic and non-diabetic patients with COVID 19. A link between D-dimer and mortality has also been established.Materials A retrospective study was carried out at the University Hospital Center of Oujda (Morocco) from November 01st to December 01st, 2020. Our study population was divided into two groups: a diabetic group and a second group without diabetes to compare clinical and biological characteristics between the two groups. In addition, the receiver operator characteristic curve was used to assess the optimal D-dimer cut-off point for predicting mortality in diabetics.Results 201 confirmed-COVID-19-patients were included in the final analysis. The median age was 64 (IQR 56-73), and 56% were male. Our study found that D-dimer levels were statistically higher in diabetic patients compared to non-diabetic patients. (1745 vs 845 respectively, P = 0001). D-dimer level > 2885 ng/mL was a significant predictor of mortality in diabetic patients with a sensitivity of 71,4% and a specificity of 70,7%.Conclusion Our study found that diabetics with COVID-19 are likely to develop hypercoagulation with a poor prognosis.

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