Open AccessThe Incidence and Location of Deep Vein Thrombosis in Lower Extremity Fracture Patients Receiving Sequential Chemical Prophylaxis
Author(s) -
Pengfei Wang,
Bin-Fei Zhang,
Hao Xue,
Yan Zhuang,
Li Zhong,
Yanjun Zhu,
Ping Liu
Publication year - 2021
Publication title -
clinical and applied thrombosis/hemostasis
Language(s) - English
Resource type - Journals
eISSN - 1938-2723
pISSN - 1076-0296
DOI - 10.1177/1076029620987630
Subject(s) - medicine , deep vein , incidence (geometry) , surgery , thrombosis , rivaroxaban , warfarin , physics , optics , atrial fibrillation
To investigate the incidence and location of deep vein thrombosis (DVT) in patients with lower extremity fractures receiving pharmacological thromboprophylaxis with LMWH followed by rivaroxaban. All patients aged ≥18 years with lower extremity fractures were included in the study. Duplex ultrasonography (DUS) was performed in the lower extremities before and after surgery for DVT evaluation. According to the location, the DVT was divided into proximal, distal, and mixed thromboses. According to fracture location, patients were classified as having fractures proximal, around, and distal to the knee. All patients received sequential chemical prophylaxis. A total of 404 patients with a mean age of 44.2 ± 13.8 years were included. The incidence of DVT postoperatively was higher than that preoperatively and at 1 month postoperatively. Patients with fractures proximal and around the knee had higher DVT incidences detected on DUS postoperatively and at 1 month postoperatively. Most DVTs were located in the distal vein. DVT incidence and severity were the highest immediately after surgery. DVT incidence in fractures around and proximal to the knee increased after surgery and at 1 month postoperatively. Although with chemical thromboprophylaxis, distal DVT was the most variable during the early stage.