Sodium Nitrite–Mediated Cardioprotection in Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction: A Cost-Effectiveness Analysis | Zendy

Daniel A. Jones | Zendy; Peter Whittaker | Zendy; Krishnaraj S. Rathod | Zendy; Amy J. Richards | Zendy; Mervyn Andiapen | Zendy; Sotiris Antoniou | Zendy; Anthony Mathur | Zendy; Amrita Ahluwalia | Zendy

Open Access

Sodium Nitrite–Mediated Cardioprotection in Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction: A Cost-Effectiveness Analysis

Author(s) -

Daniel A. Jones,

Peter Whittaker,

Krishnaraj S. Rathod,

Amy J. Richards,

Mervyn Andiapen,

Sotiris Antoniou,

Anthony Mathur,

Amrita Ahluwalia

Publication year - 2018

Publication title -

journal of cardiovascular pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.787

H-Index - 50

eISSN - 1940-4034

pISSN - 1074-2484

DOI - 10.1177/1074248418784940

Subject(s) - medicine , conventional pci , percutaneous coronary intervention , myocardial infarction , cardiology , mace

In the follow-up of patients in a trial of intracoronary sodium nitrite given during primary percutaneous coronary intervention (PCI) after acute myocardial infarction (AMI), we found a reduction in the incidence of major adverse cardiac events (MACEs). Specifically, MACE rates were 5.2% versus 25.0% with placebo at 3 years ( P = .013). Such MACE reductions should also be associated with economic benefit. Thus, we assessed the cost utility of sodium nitrite therapy versus standard primary PCI only.

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